Human Sera
Cayman Chemical 5 7-DImethoxyflavon 50mg
A carcinogen and anticancer agent neonatal administration induces the formation of hepatomas and pulmonary adenocarcinomas in adult mice at 600 Ug/animal s.c. inhibits tumor growth in an EO771 murine mammary carcinoma model from 3-110 mg/kg
Cayman Chemical Nmethyl Perfluoroctnsulfo 50mg
A bacterial neuraminidase inhibitor (Ki 48 UM for the A. sialophilus enzyme)
Cayman Chemical SeralutInIb 50mg
An ACC inhibitor (IC50s 3.5 and 4.1 nM for human ACC1 and ACC2 respectively) inhibits production of palmitate and total fatty acid content in A549 cells at 500 nM induces apoptosis and ER stress in A549 cells at 500 nM inhibits fatty acid synthesis and reduces tumor growth in an A549 mouse xenograft model at 25 mg/kg twice per day
Cayman Chemical PerfluorohexnsulfonamIde 50mg
A Bcr-Abl inhibitor (IC50 1.2 nM) selective for Bcr-Abl over VEGFR2 c-Src EGFR and HER2 at 1 UM but does inhibit PDGFRB and c-Kit (IC50s 307.6 and 665.5 nM respectively) inhibits the proliferation of K562 cells expressing wild-type Bcr-Abl (IC50 5.1 nM) and 32D cells expressing the Bcr-Abl mutations Bcr-AblQ252H Bcr-AblY253F Bcr-AblE255K Bcr-AblM351T and Bcr-AblH396P (IC50s 76.3 40.4 123.2 20.2 and 34.6 nM respectively) which are resistant to imatinib induces tumor regression and increases survival time in a K562 mouse xenograft model at 75 mg/kg per day increases the viability of SARS-CoV-2-infected Vero E6 cells (EC50 1.6 UM)
Cayman Chemical ErgoloIdmesylates 100mg
A calcium channel blocker with analgesic effects (ED50 2.5 mg/kg in STZ-induced diabetic rats) does not inhibit rotarod performance (ID50 9.4 mg/kg) or locomotor activity (ID50 43.9 mg/kg) at its effective dose
Cayman Chemical BrIvnIb AlnInate 50mg
An inhibitor of KSR-dependent MAPK signaling inhibits ATPbiotin binding to KSR2 in KSR2-MEK1 complexes (IC50 120 nM) stabilizes KSR2 in an inactive state reduces interactions between B-RAF and KSR2-MEK1 complexes inhibits KSR-stimulated phosphorylation of MEK and ERK in HEK293H cells at 5 M enhances the efficacy of trametinib further reducing cell viability in K-Ras mutant HCT116 and A549 cell lines but not B-RAF mutant SK-MEL-239 and A375 cell lines at 1 M
Cayman Chemical Acrvastn 50mg
An intermediate in the pentose phosphate pathway carbon fixation in photosynthetic organisms and the biosynthesis of lipopolysaccharide amino acids secondary metabolites and antibiotics
Cayman Chemical Flumethason 50mg
A FLT3 inhibitor (IC50 5 nM for the wild-type enzyme) inhibits various FLT3 mutants (IC50s 1.4-12.2 nM) also inhibits Axl and c-Kit (IC50s 41 and 102 nM respectively) decreases the viability of blast cells isolated from patients with relapsed AML in a concentration-dependent manner
Cayman Chemical RaltItrexed 50mg
A Chk1 inhibitor (Ki 0.9 nM) IC50 values of 2/M checkpoint in HeLa cells induces apoptosis in gastric cancer cell lines
Cayman Chemical PAMAM DendrImR G6 0 AmInw 50mg
A dehydroxylated derivative of uridine inhibits uridine phosphorylase isolated from T. gondii (apparent Ki 2.459 mM) decreases the proliferation of CCRF CEM L1210 P388 and S180 cancer cells (EC50s 25 5 2.5 and 15 UM respectively) reduces the infection rate and number of T. cruzi amastigotes in HeLa cells at 1 UM induces sodium currents in X. laevis oocytes expressing human CNT 1 or CNT 3 at 500 UM
Cayman Chemical 1Stearoyl2MyrIstoylsngly 50mg
An analog of PCA inhibits the reuptake of serotonin (IC50 330 nM) and dopamine (IC50 2.3 M)
Cayman Chemical RamosetronhydrochlorIde 50mg
A selective potent and cell-permeable inhibitor of mTOR (IC50 4.3 nM) which blocks signaling through both mTORC1 and mTORC2 induces G1 cell cycle arrest in both rapamycin-sensitive and rapamycin-resistant cancer cell lines and reduces tumor growth in nude mice with PTEN-null tumors
Cayman Chemical TetrahydroharmIn 50mg
A natural non-caloric sweetener increases GLP-1 secretion in a 2-D mouse intestine model mice prefer rebaudioside A water to unsweetened water
Cayman Chemical PalIperIdon 100mg
An unusual fatty acid that acylates some Myxococcus species a group of gram-negative bacteria found mainly in soil and also common to marine and freshwater systems with quorum sensing capabilities