Human Sera
Cayman Chemical 2AmIno6 7dIhydroxy1 2 50mg
A dopamine receptor agonist (EC50s = 3.5 and 0.65 μM in rat striatal and nucleus accumbens homogenates, respectively); stimulates production of cAMP in rat striatal homogenates, a process that is reduced by 70% in the presence of dopamine antagonist fluphenazine at a concentration of 1 μM; induces hyperlocomotion in rats when injected bilaterally at a dose of 100 nmol per side into the nucleus accumbens; increases cAMP production and glycoprotein secretion in the albumen gland of H. duryi (snail); reduces sucrose feeding in R. maderae (cockroach) nymphs
Cayman Chemical MetergolIn 100mg
A serotonin receptor antagonist active at 5-HT1 (pKi = 7.8 for 5-HT1B), 5-HT2, (pKi = 8.64, 8.75, and 8.75 for 5-HT2A, 5-HT2B, and 5-HT2C respectively), and 5-HT7 receptors; blocks 5-HT7 receptor-stimulated cAMP production (IC50 = 321 nM); dose-dependently inhibits voltage-dependent sodium and potassium channels
Cayman Chemical 2 5-nhydro-D-mnItol 50mg
An antimetabolic fructose analogue that increases food intake in rats
Cayman Chemical GrazoprevIr 50mg
An NS3/4A protease inhibitor; has in vitro activity against major HCV genotypes (Kis = 0.1, 0.1, 0.08, 0.15, and 0.9 nM for genotypes 1a, 1b, 2a, 2b, and 3a, respectively); has in vitro activity against common HCV resistance genotypes (Kis = 0.07, 0.14, and 0.30 for genotypes 1b R155K, D165V, and D168Y, respectively); inhibits the NS3/4A protease in an in vitro replicon system (EC50s = 2 and 8 nM for genotypes 1a and 2a, respectively)
Cayman Chemical BazedoxIfenacetate 50mg
An indole-based SERM that binds to both ERα (IC50 = 26 nM) and ERβ (IC50 = 99 nM); antagonizes 17β-estradiol-dependent and hormone-independent growth of breast cancer cell proliferation (80% reduction with 10 nM) in a manner related to cell cycle arrest and downregulation of cyclin D1 and ERα
Cayman Chemical VulpInIc AcId 100mg
A lichen metabolite with diverse biological activities; active against various bacteria (MICs = 4-16 μg/ml); prevents UVB-induced apoptosis, cytotoxicity, and cytoskeletal modifications in HaCaT human keratinocytes from 25-800 μM; increases scratch wound healing of HaCaT cells; reduces hydrogen peroxide-induced production of ROS and cytotoxicity in HUVECs at 15 μM
Cayman Chemical EsmololhydrochlorIde 100mg
A β1-AR antagonist; binds to β1-ARs (Kd = 100 nM in isolated cardiac myocytes); 34-fold selective for β1- over β2-ARs; inhibits ICa.L and the INa in rat cardiac myocytes (IC50s = 50 and 169 μM, respectively)
Cayman Chemical Buparvaquon 100mg
An inhibitor of cytochrome bc1 in the parasites T. annulata and T. parva (in vitro EC50 of 1.5 x 10-8 M and 6.1 x 10-10 M, respectively)
Cayman Chemical AfatInIbmaleate 100mg
An inhibitor of EGFR and ErbB2 (IC50s = 0.5 and 14 nM, respectively); increases the cytotoxicity of adriamycin in a concentration-dependent manner in multidrug-resistant A549T lung cancer cells overexpressing P-glycoprotein; reduces tumor growth in ErbB2-amplified NCI-N87 and NUGC4 gastric cancer mouse xenograft models at 20 mg/kg
Cayman Chemical DnofloxacInmesylate 100mg
A fluroquinolone antibiotic; has activity against 68 field isolates of Mycoplasma species isolated from cattle, swine, and poultry (MICs = 8-500 nM); protective in vivo against P. multocida, E. coli, and S. choleraesuis in mice with protective doses of 0.31, 0.40, and 2.42 mg/kg, respectively
Cayman Chemical 3-PropylxnthIn 50mg
A xanthine derivative that antagonizes adenosine receptors (Kis = 44, 32, and 6.3 µM for A1, A2A, and A2B, respectively) and cAMP PDE(Ki = 42 µM); induces smooth muscle relaxation, blocks smooth muscle contraction and VEGF secretion driven by adenosine receptor agonists, and reduces bronchial hyperresponsiveness
Cayman Chemical HydroflumethIazIde 100mg
A thiazide diuretic; inhibitor of carbonic anhydrase (CA); selective for CAII, VB, VII, IX, XII, and XIV (Kis = 305-235 nM) over CAI, IV, and VI (Kis = 2,840-8,250 nM) and CAIII, VA, and XIII (Kis = >10 µM)
Cayman Chemical Zaltoprofen 100mg
An NSAID that displays slight preferential inhibition for COX-2 (IC50s = 1.3 and 0.34 μM for COX-1 and COX-2, respectively); also inhibits bradykinin-induced nociceptive responses by blocking the activation of PKC
Cayman Chemical GalntamInhydrobromIde 50mg
An alkaloid with AChE inhibitory and nAChR potentiating activities; selectively inhibits AChE over BChE (IC50s = 636 and 8,404 nM, respectively); potentiates ACh-induced currents in HEK293 cells expressing human α4β2 subunit-containing nAChRs at 0.5 µM; decreases escape latency and path length in the Morris water maze in the APP23 transgenic mouse model of Alzheimer's disease at 1.3 mg/kg per day
Cayman Chemical ClevIdIpIn 100mg
An inhibitor of L-type calcium channels (IC50s = 7.1 and 78.8 nM at -40 and -80 mV, respectively, in isolated guinea pig cardiomyocytes); preferentially inhibits L-type calcium channels in isolated rat portal vein over rat left ventricle (IC50s = 427 and 20,417 nM, respectively); decreases mean arterial pressure in anesthetized normotensive or spontaneously hypertensive rats (ED30s = 316 and 58 nmol/kg, respectively)